One day, six-year-old Dottie McStuffins wants to become a Doctor, like her mother. She has set up a practice in her playhouse in the garden, where she touchingly cares for poorly toys and dolls. That's why everyone calls her Doc stuffing. And when she examines her patients using her stethoscope, something magical happens: they come to life and talk to her. After a thorough examination by Doc McStuffins, they all feel better, because she is the best Doctor you could wish for.